The Montreal International Symposium on Angiogenesis and Metastasis aims at bringing together scientists, clinicians and their trainees from cancer research institutions to present their recent, unpublished findings in the field of angiogenesis and metastasis.
Angiogenesis and Metastasis are two critical and interconnected processes, during which cancer becomes a progressive, systemic and lethal disease through the involvement of the vascular system. Blood vessel networks that normally integrate the various physiological roles of individual cells, tissues and organs are hijacked and exploited by a growing tumour. In the process, the intricate controls that govern homeostasis and formation of blood vessels and lymphatics become profoundly compromised, leading to unscheduled vascular expansion (tumour angiogenesis), abnormal blood vessel remodeling and development of a ‘parasitic’ tumour microcirculation. This process fuels and shapes the disease progression, controls the distribution, and response to anticancer therapeutics, and shedding of cancer cells to systemic circulation, a precondition for establishment of secondary angiogenesis-dependent tumours in distant sites (metastasis). This ‘vascular sequence’ represents the ultimate threat and a formidable therapeutic challenge.